GLOW 70mg

BPC-157 & TB-500 Peptide Blend

This research blend combines three well-studied peptides with complementary mechanisms:

• BPC-157 (Body Protection Compound-157) — a synthetic pentadecapeptide investigated for its potential roles in tissue repair, angiogenesis, and modulation of inflammatory pathways.
• TB-500 (Thymosin Beta-4) — a synthetic 43-amino-acid peptide studied for its involvement in actin regulation, cell migration, wound healing, and angiogenesis.

The combination is explored in laboratory settings for possible synergistic support of regenerative processes, including inflammation modulation, vascular growth, and extracellular matrix repair.

Specifications

BPC-157 • Molecular Formula: C62H98N16O22 • Molecular Weight: 1419.5 g/mol • Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

TB-500 (Thymosin Beta-4) • Molecular Formula: C212H350N56O78S • Molecular Weight: 4963 g/mol • Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

BPC-157 & TB-500

Anti-Inflammatory Signaling All three peptides have been individually studied for their potential to modulate inflammatory pathways. TB-500 has been linked to upregulation of miR-146a, which may suppress TLR signaling proteins (IRAK1 and TRAF6) and downstream NF-κB activation. BPC-157 has been associated with reduced inflammatory cell infiltration, lower levels of markers such as myeloperoxidase, leukotriene B4, and thromboxane B2, and possible protection of endothelial integrity via nitric oxide pathways.

Cellular Regeneration and Angiogenesis The blend is researched for complementary effects on tissue repair. TB-500 is studied for its actin-binding domain (LKKTETQ), which may enhance cell motility, endothelial migration, and tube formation through Notch/NF-κB and VEGF/Ang2-Tie2 pathways. BPC-157 has been linked to enhanced fibroblast migration, FAK-paxillin signaling, Egr-1 expression, and vascular protection.

Collagen Repair and Wound Healing Preclinical data suggest the peptides may support extracellular matrix remodeling. TB-500 has been associated with improved collagen fiber alignment and mechanical properties in ligament and tendon models. BPC-157 has been linked to accelerated tendon outgrowth, fibroblast survival under oxidative stress, and increased collagen deposition.

Potential Synergism Although direct combination studies are limited, researchers hypothesize that the blend may offer broader regenerative support through overlapping yet distinct mechanisms: cytoskeletal dynamics and cell migration (TB-500), and growth factor and vascular signaling (BPC-157).

Important Disclaimer The products mentioned are intended strictly for laboratory research and in-vitro experimentation. They are not for human or animal consumption. Bodily introduction is strictly prohibited. All information provided is for educational purposes only and does not constitute medical advice. Always refer to our terms and conditions.

This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on this site is strictly for educational purposes only. Refer to our terms and conditions for more details.

References

1. Seiwerth S, et al. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in pharmacology, 12, 627533.
2. Maar K, et al. (2021). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4… Cells, 10(6), 1343.
3. Maquart FX, et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett.
4. Santra M, et al. (2014). Thymosin β4 up-regulation of microRNA-146a… Journal of biological chemistry.
5. Sikiric P, et al. (2012). Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157. Current Medical Chemistry.
6. Lv S, et al. (2020). Thymosin‑β 4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway. International Journal of Molecular Medicine.
7. Sikiric P, et al. (2016). Brain-gut Axis and Pentadecapeptide BPC 157. Current Neuropharmacology.
8. Mulder GD, et al. (1994). Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-l-histidyl-l-lysine copper. Wound Repair and Regeneration.
9. Xu B, et al. (2013). Thymosin β4 enhances the healing of medial collateral ligament injury in rats. Regulatory Peptides.
10. Chang CH, et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing… Journal of Applied Physiology.